| 1. Jornada | 22.07.2018 | UANL Tigres | - | Club León | 2:0 | ||||
| 2. Jornada | 30.07.2018 | Club León | - | CF Monterrey | 0:2 | ||||
| 3. Jornada | 06.08.2018 | Club Tijuana | - | Club León | 1:1 |  |
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| 4. Jornada | 12.08.2018 | Club León | - | Gallos Blancos | 4:0 | ||||
| 5. Jornada | 19.08.2018 | Cruz Azul | - | Club León | 3:0 | ||||
| 8. Jornada | 02.09.2018 | Club León | - | Pumas UNAM | 1:2 | ||||
| 10. Jornada | 23.09.2018 | Club León | - | Lobos BUAP | 0:1 | ||||
| 11. Jornada | 29.09.2018 | CD Veracruz | - | Club León | 0:4 | |
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| 12. Jornada | 07.10.2018 | Club León | - | Monarcas Morelia | 1:2 | |
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| 14. Jornada | 29.10.2018 | Club León | - | Puebla FC | 0:4 | ||||
| 15. Jornada | 05.11.2018 | Atlas Guadalajara | - | Club León | 0:0 |
Paraguay