| 1. Jornada | 17.07.2022 | Club Olimpia | - | Guaraní | 2:0 |  |
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| 2. Jornada | 20.07.2022 | Libertad | - | Club Olimpia | 4:2 | ||||
| 3. Jornada | 24.07.2022 | Club Olimpia | - | Guaireña FC | 2:1 | ||||
| 4. Jornada | 31.07.2022 | Tacuary | - | Club Olimpia | 2:1 | ||||
| 5. Jornada | 08.08.2022 | Club Olimpia | - | Sportivo Ameliano | 2:0 | ||||
| 7. Jornada | 20.08.2022 | General Caballero DJLM | - | Club Olimpia | 0:2 | ||||
| 9. Jornada | 04.09.2022 | 12 de Octubre de Itauguá | - | Club Olimpia | 1:3 | ||||
| 11. Jornada | 16.09.2022 | Club Nacional | - | Club Olimpia | 1:1 | ||||
| 12. Jornada | 20.09.2022 | Guaraní | - | Club Olimpia | 2:1 | ||||
| 21. Jornada | 08.11.2022 | Sol de América | - | Club Olimpia | 0:2 |  |
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| 22. Jornada | 12.11.2022 | Club Olimpia | - | Club Nacional | 1:1 |
Paraguay