| 1. Jornada | 06.02.2022 | San Francisco FC | - | Veraguas United | 0:1 | ||||
| 3. Jornada | 20.02.2022 | Atlético Chiriquí | - | San Francisco FC | 2:1 | ||||
| 11. Jornada | 09.04.2022 | Potros del Este | - | San Francisco FC | 0:0 | ||||
| 13. Jornada | 24.04.2022 | Independiente de La Chorrera | - | San Francisco FC | 1:4 |  |
|||
| 14. Jornada | 27.04.2022 | San Francisco FC | - | Atlético Chiriquí | 2:2 | ||||
| 15. Jornada | 30.04.2022 | UD Universitario | - | San Francisco FC | 0:1 | |
|||
| 16. Jornada | 08.05.2022 | San Francisco FC | - | Herrera FC | 3:1 |
Panamá