| 3. Jornada | 24.07.2022 | General Caballero DJLM | - | Libertad | 3:2 |  |
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| 4. Jornada | 29.07.2022 | Guaireña FC | - | General Caballero DJLM | 1:2 | ||||
| 5. Jornada | 06.08.2022 | General Caballero DJLM | - | Tacuary | 0:4 | |
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| 7. Jornada | 20.08.2022 | General Caballero DJLM | - | Club Olimpia | 0:2 | ||||
| 12. Jornada | 19.09.2022 | Club Nacional | - | General Caballero DJLM | 1:0 | ||||
| 13. Jornada | 24.09.2022 | General Caballero DJLM | - | Guaraní | 3:0 | ||||
| 14. Jornada | 03.10.2022 | Libertad | - | General Caballero DJLM | 1:0 | |
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| 16. Jornada | 12.10.2022 | Tacuary | - | General Caballero DJLM | 0:3 |  |
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| 17. Jornada | 16.10.2022 | General Caballero DJLM | - | Sportivo Ameliano | 2:0 | |
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| 18. Jornada | 23.10.2022 | Club Olimpia | - | General Caballero DJLM | 2:1 | |
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| 20. Jornada | 01.11.2022 | General Caballero DJLM | - | Resistencia SC | 1:0 | ||||
| 21. Jornada | 08.11.2022 | 12 de Octubre de Itauguá | - | General Caballero DJLM | 0:3 | ||||
| 22. Jornada | 13.11.2022 | General Caballero DJLM | - | Sol de América | 0:0 |
Paraguay