| 1. Jornada | 12.03.2021 | Real Tomayapo | - | Always Ready | 1:0 | ||||
| 2. Jornada | 15.03.2021 | Royal Pari | - | Real Tomayapo | 4:2 | ||||
| 3. Jornada | 02.04.2021 | Real Tomayapo | - | Real Potosí | 0:0 | ||||
| 5. Jornada | 25.04.2021 | Real Tomayapo | - | Blooming | 2:1 | ||||
| 6. Jornada | 02.05.2021 | Bolívar | - | Real Tomayapo | 2:0 |  |
|||
| 7. Jornada | 11.05.2021 | Real Tomayapo | - | Club Aurora | 1:2 | ||||
| 13. Jornada | 05.08.2021 | The Strongest | - | Real Tomayapo | 2:0 | ||||
| 14. Jornada | 08.08.2021 | Real Tomayapo | - | Jorge Wilstermann | 1:2 | ||||
| 15. Jornada | 14.08.2021 | Atlético Palmaflor | - | Real Tomayapo | 2:0 | ||||
| 16. Jornada | 17.08.2021 | Always Ready | - | Real Tomayapo | 3:1 |  |
|
||
| 21. Jornada | 26.09.2021 | Real Tomayapo | - | Bolívar | 1:3 | |
|||
| 22. Jornada | 17.10.2021 | Club Aurora | - | Real Tomayapo | 1:2 | ||||
| 23. Jornada | 24.10.2021 | Independiente Petrolero | - | Real Tomayapo | 1:0 | ||||
| 24. Jornada | 28.10.2021 | Real Tomayapo | - | Club San José | 1:0 | ||||
| 25. Jornada | 01.11.2021 | Real Santa Cruz | - | Real Tomayapo | 2:0 | ||||
| 26. Jornada | 23.11.2021 | Real Tomayapo | - | Nacional Potosí | 3:0 |
Uruguay