| 1. Jornada | 16.01.2022 | CD Águila | - | Jocoro FC | 0:0 | ||||
| 2. Jornada | 22.01.2022 | Jocoro FC | - | Alianza | 3:2 | ||||
| 3. Jornada | 26.01.2022 | Jocoro FC | - | FAS | 2:2 | ||||
| 4. Jornada | 30.01.2022 | Santa Tecla FC | - | Jocoro FC | 3:0 |  |
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| 5. Jornada | 04.02.2022 | Jocoro FC | - | Municipal Limeño | 3:0 | ||||
| 6. Jornada | 09.02.2022 | Atlético Marte | - | Jocoro FC | 0:0 | ||||
| 7. Jornada | 12.02.2022 | Jocoro FC | - | Isidro Metapán | 2:1 | ||||
| 8. Jornada | 20.02.2022 | AD Chalatenango | - | Jocoro FC | 1:0 | ||||
| 9. Jornada | 23.02.2022 | Jocoro FC | - | Luis Ángel Firpo | 1:1 | ||||
| 10. Jornada | 27.02.2022 | Platense Zacatecoluca | - | Jocoro FC | 2:0 | ||||
| 11. Jornada | 05.03.2022 | Jocoro FC | - | Once Municipal | 2:1 | ||||
| 12. Jornada | 12.03.2022 | Jocoro FC | - | CD Águila | 0:2 | ||||
| 13. Jornada | 20.03.2022 | Alianza | - | Jocoro FC | 2:1 | ||||
| 14. Jornada | 23.03.2022 | FAS | - | Jocoro FC | 2:1 | ||||
| 15. Jornada | 02.04.2022 | Jocoro FC | - | Santa Tecla FC | 1:0 | ||||
| 16. Jornada | 10.04.2022 | Municipal Limeño | - | Jocoro FC | 2:2 | ||||
| 17. Jornada | 13.04.2022 | Jocoro FC | - | Atlético Marte | 1:1 | ||||
| 18. Jornada | 17.04.2022 | Isidro Metapán | - | Jocoro FC | 3:0 | ||||
| 22. Jornada | 07.05.2022 | Once Municipal | - | Jocoro FC | 0:1 | |
El Salvador