| 1. Jornada | 06.02.2022 | 12 de Octubre de Itauguá | - | Libertad | 1:6 | ||||
| 2. Jornada | 13.02.2022 | Libertad | - | General Caballero DJLM | 1:0 |  |
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| 5. Jornada | 06.03.2022 | Libertad | - | Sportivo Ameliano | 2:0 | ||||
| 6. Jornada | 15.03.2022 | Club Nacional | - | Libertad | 0:3 | ||||
| 9. Jornada | 11.04.2022 | Libertad | - | Sol de América | 3:1 |  |
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| 13. Jornada | 30.04.2022 | General Caballero DJLM | - | Libertad | 0:1 | ||||
| 14. Jornada | 08.05.2022 | Libertad | - | Club Olimpia | 1:0 | ||||
| 15. Jornada | 11.05.2022 | Libertad | - | Tacuary | 3:0 | |
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| 16. Jornada | 15.05.2022 | Sportivo Ameliano | - | Libertad | 1:3 | ||||
| 17. Jornada | 23.05.2022 | Libertad | - | Club Nacional | 1:0 | ||||
| 22. Jornada | 03.07.2022 | Resistencia SC | - | Libertad | 0:4 | |
Paraguay