| 1. Jornada | 16.07.2022 | Sportivo Ameliano | - | Libertad | 2:0 | ||||
| 2. Jornada | 20.07.2022 | Libertad | - | Club Olimpia | 4:2 | ||||
| 3. Jornada | 24.07.2022 | General Caballero DJLM | - | Libertad | 3:2 | ||||
| 11. Jornada | 14.09.2022 | Libertad | - | Tacuary | 2:0 | ||||
| 14. Jornada | 03.10.2022 | Libertad | - | General Caballero DJLM | 1:0 |  |
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| 16. Jornada | 10.10.2022 | Libertad | - | 12 de Octubre de Itauguá | 2:2 | ||||
| 17. Jornada | 18.10.2022 | Sol de América | - | Libertad | 1:1 | ||||
| 18. Jornada | 24.10.2022 | Libertad | - | Club Nacional | 0:1 | ||||
| 21. Jornada | 06.11.2022 | Libertad | - | Guaireña FC | 4:2 |  |
Paraguay