| 1. Jornada | 14.08.2021 | Watford FC | - | Aston Villa | 3:2 | ||||
| 2. Jornada | 21.08.2021 | Brighton & Hove Albion | - | Watford FC | 2:0 | ||||
| 3. Jornada | 29.08.2021 | Tottenham Hotspur | - | Watford FC | 1:0 | ||||
| 4. Jornada | 11.09.2021 | Watford FC | - | Wolverhampton Wanderers | 0:2 | ||||
| 5. Jornada | 18.09.2021 | Norwich City | - | Watford FC | 1:3 | ||||
| 6. Jornada | 25.09.2021 | Watford FC | - | Newcastle United | 1:1 |  |
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| 7. Jornada | 02.10.2021 | Leeds United | - | Watford FC | 1:0 | ||||
| 8. Jornada | 16.10.2021 | Watford FC | - | Liverpool | 0:5 | ||||
| 9. Jornada | 23.10.2021 | Everton | - | Watford FC | 2:5 | |
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| 10. Jornada | 30.10.2021 | Watford FC | - | Southampton | 0:1 | ||||
| 12. Jornada | 20.11.2021 | Watford FC | - | Manchester United | 4:1 | ||||
| 13. Jornada | 28.11.2021 | Leicester City | - | Watford FC | 4:2 | ||||
| 14. Jornada | 01.12.2021 | Watford FC | - | Chelsea | 1:2 | |
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| 15. Jornada | 04.12.2021 | Watford FC | - | Manchester City | 1:3 | ||||
| 16. Jornada | 10.12.2021 | Brentford FC | - | Watford FC | 2:1 | ||||
| 21. Jornada | 01.01.2022 | Watford FC | - | Tottenham Hotspur | 0:1 | ||||
| 36. Jornada | 07.05.2022 | Crystal Palace | - | Watford FC | 1:0 |
Países Bajos