| 1. Jornada | 20.02.2021 | Guayaquil City | - | Macará | 3:1 |  |
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| 2. Jornada | 27.02.2021 | Deportivo Cuenca | - | Guayaquil City | 3:0 | ||||
| 3. Jornada | 08.03.2021 | Guayaquil City | - | Barcelona | 0:3 | ||||
| 4. Jornada | 13.03.2021 | Delfín SC | - | Guayaquil City | 1:1 | ||||
| 5. Jornada | 21.03.2021 | Guayaquil City | - | Universidad Catolica | 1:2 | ||||
| 7. Jornada | 01.04.2021 | Guayaquil City | - | Orense SC | 4:1 | ||||
| 6. Jornada | 05.04.2021 | Técnico Universitario | - | Guayaquil City | 3:0 | ||||
| 8. Jornada | 13.04.2021 | 9 de Octubre | - | Guayaquil City | 4:0 |  |
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| 9. Jornada | 18.04.2021 | Guayaquil City | - | LDU Quito | 2:2 | ||||
| 10. Jornada | 04.05.2021 | Olmedo | - | Guayaquil City | 0:0 | ||||
| 11. Jornada | 11.05.2021 | Guayaquil City | - | Manta | 0:3 | ||||
| 12. Jornada | 16.05.2021 | Emelec | - | Guayaquil City | 1:0 | ||||
| 13. Jornada | 22.05.2021 | Independiente del Valle | - | Guayaquil City | 3:0 | ||||
| 14. Jornada | 29.05.2021 | Guayaquil City | - | Mushuc Runa | 0:0 | ||||
| 15. Jornada | 18.07.2021 | Aucas | - | Guayaquil City | 3:0 |
Ecuador