| 2. Jornada | 13.02.2022 | Real Santa Cruz | - | CD Guabirá | 2:2 | ||||
| 3. Jornada | 18.02.2022 | Nacional Potosí | - | Real Santa Cruz | 1:0 | ||||
| 4. Jornada | 26.02.2022 | Real Santa Cruz | - | The Strongest | 1:2 |  |
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| 6. Jornada | 12.03.2022 | Real Santa Cruz | - | Always Ready | 0:1 | ||||
| 7. Jornada | 02.04.2022 | Real Santa Cruz | - | Oriente Petrolero | 2:1 | ||||
| 8. Jornada | 09.04.2022 | Atlético Palmaflor | - | Real Santa Cruz | 2:1 | |
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| 9. Jornada | 16.04.2022 | Universitario de Sucre | - | Real Santa Cruz | 2:3 | ||||
| 10. Jornada | 22.04.2022 | CD Guabirá | - | Real Santa Cruz | 1:0 | |
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| 11. Jornada | 24.04.2022 | Real Santa Cruz | - | Nacional Potosí | 3:2 | ||||
| 12. Jornada | 30.04.2022 | The Strongest | - | Real Santa Cruz | 1:1 | ||||
| 14. Jornada | 12.05.2022 | Club Aurora | - | Real Santa Cruz | 2:4 | ||||
| 15. Jornada | 14.05.2022 | Oriente Petrolero | - | Real Santa Cruz | 1:2 | |
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| 16. Jornada | 21.05.2022 | Real Santa Cruz | - | Atlético Palmaflor | 1:2 |
Rep. Dominicana