| 2. Jornada | 10.02.2021 | Club Nacional | - | Sol de América | 1:0 |  |
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| 4. Jornada | 22.02.2021 | Club Nacional | - | Libertad | 0:3 | ||||
| 5. Jornada | 01.03.2021 | Guaireña FC | - | Club Nacional | 1:0 | ||||
| 6. Jornada | 06.03.2021 | Club Nacional | - | Cerro Porteño | 2:0 | ||||
| 7. Jornada | 10.03.2021 | Club Olimpia | - | Club Nacional | 1:4 | ||||
| 8. Jornada | 13.03.2021 | River Plate | - | Club Nacional | 0:0 | |
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| 11. Jornada | 11.04.2021 | Sol de América | - | Club Nacional | 1:2 | ||||
| 12. Jornada | 17.04.2021 | Club Nacional | - | Sportivo Luqueño | 1:0 | ||||
| 13. Jornada | 26.04.2021 | Libertad | - | Club Nacional | 1:1 | ||||
| 14. Jornada | 01.05.2021 | Club Nacional | - | Guaireña FC | 1:3 |  |
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| 15. Jornada | 09.05.2021 | Cerro Porteño | - | Club Nacional | 2:2 |  |
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| 16. Jornada | 18.05.2021 | Club Nacional | - | Club Olimpia | 2:1 | ||||
| 17. Jornada | 24.05.2021 | Club Nacional | - | River Plate | 0:1 | ||||
| 18. Jornada | 31.05.2021 | 12 de Octubre de Itauguá | - | Club Nacional | 2:2 |  |
Paraguay