| 4. Jornada | 07.08.2021 | Club Nacional | - | Libertad | 1:0 | ||||
| 5. Jornada | 14.08.2021 | River Plate | - | Club Nacional | 1:0 | ||||
| 6. Jornada | 21.08.2021 | Club Nacional | - | Guaireña FC | 0:2 | ||||
| 7. Jornada | 29.08.2021 | Cerro Porteño | - | Club Nacional | 0:2 |  |
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| 8. Jornada | 11.09.2021 | Club Nacional | - | Sol de América | 1:1 |  |
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| 9. Jornada | 21.09.2021 | Club Olimpia | - | Club Nacional | 1:2 | ||||
| 10. Jornada | 26.09.2021 | Club Nacional | - | 12 de Octubre de Itauguá | 1:1 | |
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| 12. Jornada | 17.10.2021 | Club Nacional | - | Sportivo Luqueño | 0:0 | |
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| 13. Jornada | 25.10.2021 | Libertad | - | Club Nacional | 1:2 | ||||
| 14. Jornada | 30.10.2021 | Club Nacional | - | River Plate | 1:1 | |
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| 15. Jornada | 09.11.2021 | Guaireña FC | - | Club Nacional | 0:0 | ||||
| 16. Jornada | 22.11.2021 | Club Nacional | - | Cerro Porteño | 1:5 | ||||
| 18. Jornada | 05.12.2021 | Club Nacional | - | Club Olimpia | 1:3 |
Paraguay