| 2. Jornada | 23.01.2022 | Atlético Marte | - | Luis Ángel Firpo | 2:1 | ||||
| 5. Jornada | 06.02.2022 | Alianza | - | Luis Ángel Firpo | 0:0 |  |
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| 6. Jornada | 10.02.2022 | Luis Ángel Firpo | - | Platense Zacatecoluca | 1:1 | |
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| 7. Jornada | 13.02.2022 | Once Municipal | - | Luis Ángel Firpo | 1:0 | ||||
| 8. Jornada | 20.02.2022 | Luis Ángel Firpo | - | CD Águila | 0:0 | ||||
| 9. Jornada | 23.02.2022 | Jocoro FC | - | Luis Ángel Firpo | 1:1 | |
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| 10. Jornada | 27.02.2022 | Luis Ángel Firpo | - | FAS | 2:3 | |
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| 11. Jornada | 06.03.2022 | Santa Tecla FC | - | Luis Ángel Firpo | 1:5 | ||||
| 12. Jornada | 13.03.2022 | Municipal Limeño | - | Luis Ángel Firpo | 3:2 | ||||
| 13. Jornada | 20.03.2022 | Luis Ángel Firpo | - | Atlético Marte | 1:2 | ||||
| 16. Jornada | 10.04.2022 | Luis Ángel Firpo | - | Alianza | 0:1 | ||||
| 17. Jornada | 13.04.2022 | Platense Zacatecoluca | - | Luis Ángel Firpo | 1:2 | ||||
| 18. Jornada | 17.04.2022 | Luis Ángel Firpo | - | Once Municipal | 0:0 | ||||
| 19. Jornada | 24.04.2022 | CD Águila | - | Luis Ángel Firpo | 1:0 | ||||
| 20. Jornada | 28.04.2022 | Luis Ángel Firpo | - | Jocoro FC | 1:0 | ||||
| 21. Jornada | 01.05.2022 | FAS | - | Luis Ángel Firpo | 0:1 | ||||
| 22. Jornada | 07.05.2022 | Luis Ángel Firpo | - | Santa Tecla FC | 2:0 |
El Salvador