| 1. Jornada | 08.01.2022 | Cruz Azul [Sub 18] | - | Club Tijuana [Sub 18] | 3:2 | ||||
| 2. Jornada | 15.01.2022 | Club Tijuana [Sub 18] | - | Club León [Sub 18] | 1:2 |  |
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| 6. Jornada | 18.02.2022 | Club Tijuana [Sub 18] | - | Club Necaxa [Sub 18] | 3:2 | ||||
| 7. Jornada | 25.02.2022 | Club Tijuana [Sub 18] | - | Atlas Guadalajara [Sub 18] | 3:3 | ||||
| 11. Jornada | 18.03.2022 | Club Tijuana [Sub 18] | - | FC Juárez [Sub 18] | 3:2 | ||||
| 12. Jornada | 03.04.2022 | UANL Tigres [Sub 18] | - | Club Tijuana [Sub 18] | 2:0 | ||||
| 14. Jornada | 15.04.2022 | Club Tijuana [Sub 18] | - | CF América [Sub 18] | 2:0 |
México