| 6. Jornada | 18.08.2022 | Birmingham Legion | - | Detroit City FC | 1:2 | ||||
| 6. Jornada | 21.08.2022 | Detroit City FC | - | Louisville City FC | 0:1 | ||||
| 6. Jornada | 28.08.2022 | Charleston Battery | - | Detroit City FC | 0:3 | ||||
| 7. Jornada | 04.09.2022 | Detroit City FC | - | Indy Eleven | 0:0 | ||||
| 7. Jornada | 11.09.2022 | Colorado Springs Switchbacks | - | Detroit City FC | 1:2 |  |
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| 7. Jornada | 18.09.2022 | Detroit City FC | - | Tampa Bay Rowdies | 1:0 | ||||
| 7. Jornada | 22.09.2022 | New York RB II | - | Detroit City FC | 0:0 | ||||
| 7. Jornada | 25.09.2022 | Detroit City FC | - | FC Tulsa | 2:2 |  |
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| 8. Jornada | 02.10.2022 | Loudoun United | - | Detroit City FC | 0:4 | |
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| 8. Jornada | 06.10.2022 | Louisville City FC | - | Detroit City FC | 2:1 | ||||
| 8. Jornada | 15.10.2022 | Detroit City FC | - | Miami FC | 0:1 |
Sudáfrica