| 1. Jornada | 18.07.2021 | Arsenal de Sarandí | - | San Lorenzo | 1:1 |  |
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| 2. Jornada | 24.07.2021 | San Lorenzo | - | Central Córdoba SdE | 1:0 | ||||
| 3. Jornada | 28.07.2021 | Boca Juniors | - | San Lorenzo | 0:2 | |
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| 4. Jornada | 02.08.2021 | San Lorenzo | - | Banfield | 1:1 | |
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| 5. Jornada | 07.08.2021 | Unión de Santa Fe | - | San Lorenzo | 4:0 | ||||
| 10. Jornada | 04.09.2021 | Platense | - | San Lorenzo | 1:1 | ||||
| 11. Jornada | 13.09.2021 | San Lorenzo | - | Racing Club | 1:1 | |
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| 12. Jornada | 20.09.2021 | Rosario Central | - | San Lorenzo | 1:0 | |
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| 14. Jornada | 02.10.2021 | Atlético Tucumán | - | San Lorenzo | 0:0 | ||||
| 16. Jornada | 18.10.2021 | River Plate | - | San Lorenzo | 3:1 | ||||
| 17. Jornada | 20.10.2021 | San Lorenzo | - | CA Lanús | 1:3 | |
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| 18. Jornada | 24.10.2021 | Huracán | - | San Lorenzo | 2:1 | |
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| 19. Jornada | 31.10.2021 | San Lorenzo | - | Godoy Cruz | 1:0 | ||||
| 20. Jornada | 07.11.2021 | Vélez Sarsfield | - | San Lorenzo | 2:1 | |
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| 21. Jornada | 19.11.2021 | San Lorenzo | - | Gimnasia de La Plata | 0:1 | ||||
| 22. Jornada | 23.11.2021 | Aldosivi | - | San Lorenzo | 2:0 | ||||
| 23. Jornada | 30.11.2021 | San Lorenzo | - | Sarmiento de Junín | 1:0 | ||||
| 24. Jornada | 05.12.2021 | Independiente | - | San Lorenzo | 1:1 | |
Colombia