| 7. Jornada | 29.08.2022 | San Francisco FC | - | Alianza | 0:1 | ||||
| 8. Jornada | 03.09.2022 | San Francisco FC | - | Tauro FC | 1:2 | ||||
| 9. Jornada | 12.09.2022 | Sporting San Miguelito | - | San Francisco FC | 2:1 |  |
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| 10. Jornada | 17.09.2022 | Plaza Amador | - | San Francisco FC | 1:2 | ||||
| 11. Jornada | 24.09.2022 | San Francisco FC | - | Potros del Este | 2:0 | |
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| 13. Jornada | 01.10.2022 | San Francisco FC | - | Independiente de La Chorrera | 0:2 | ||||
| 14. Jornada | 09.10.2022 | Atlético Chiriquí | - | San Francisco FC | 0:4 | ||||
| 15. Jornada | 15.10.2022 | San Francisco FC | - | Veraguas United | 1:1 | ||||
| 16. Jornada | 23.10.2022 | Herrera FC | - | San Francisco FC | 0:2 |
Panamá