| 1. Jornada | 16.01.2022 | Sololá FC | - | Cobán Imperial | 0:0 | ||||
| 2. Jornada | 22.01.2022 | Cobán Imperial | - | Comunicaciones | 2:0 | ||||
| 4. Jornada | 02.02.2022 | Cobán Imperial | - | Xelaju MC | 3:1 | ||||
| 6. Jornada | 10.02.2022 | Antigua GFC | - | Cobán Imperial | 0:1 | ||||
| 7. Jornada | 12.02.2022 | Cobán Imperial | - | Iztapa | 2:0 | ||||
| 9. Jornada | 27.02.2022 | Cobán Imperial | - | Achuapa | 0:1 |  |
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| 10. Jornada | 02.03.2022 | Santa Lucía | - | Cobán Imperial | 2:1 | ||||
| 11. Jornada | 06.03.2022 | Cobán Imperial | - | Deportivo Guastatoya | 0:0 | ||||
| 12. Jornada | 12.03.2022 | Cobán Imperial | - | Sololá FC | 2:1 | ||||
| 14. Jornada | 26.03.2022 | Cobán Imperial | - | Deportivo Malacateco | 1:1 | ||||
| 16. Jornada | 09.04.2022 | Cobán Imperial | - | Nueva Concepción | 5:1 |  |
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| 19. Jornada | 13.04.2022 | Cobán Imperial | - | CSD Municipal | 1:1 | ||||
| 17. Jornada | 16.04.2022 | Cobán Imperial | - | Antigua GFC | 0:0 |
Guatemala