| 1. Jornada | 25.07.2021 | Desna Chernigov | - | Chernomorets Odessa | 3:0 |  |
|||
| 2. Jornada | 01.08.2021 | FK Mariupol | - | Desna Chernigov | 1:2 | |
|||
| 3. Jornada | 09.08.2021 | Desna Chernigov | - | Inhulets Petrove | 2:0 | ||||
| 4. Jornada | 14.08.2021 | Desna Chernigov | - | SK Dnipro-1 | 2:1 | ||||
| 6. Jornada | 29.08.2021 | Desna Chernigov | - | NK Veres | 0:4 | |
|||
| 7. Jornada | 12.09.2021 | Vorskla Poltava | - | Desna Chernigov | 2:2 | |
|||
| 9. Jornada | 26.09.2021 | Desna Chernigov | - | Metalist 1925 Kharkiv | 1:2 | ||||
| 10. Jornada | 03.10.2021 | Zorya Lugansk | - | Desna Chernigov | 2:0 | ||||
| 11. Jornada | 17.10.2021 | FC Mynai | - | Desna Chernigov | 0:0 | ||||
| 12. Jornada | 22.10.2021 | Desna Chernigov | - | FK Oleksandriya | 1:1 | ||||
| 13. Jornada | 30.10.2021 | Shakhtar Donetsk | - | Desna Chernigov | 4:1 | ||||
| 14. Jornada | 07.11.2021 | FK Lviv | - | Desna Chernigov | 0:2 | ||||
| 15. Jornada | 21.11.2021 | Desna Chernigov | - | Kolos Kovalivka | 0:1 |  |
|||
| 17. Jornada | 05.12.2021 | Desna Chernigov | - | FK Mariupol | 3:3 | ||||
| 18. Jornada | 10.12.2021 | Inhulets Petrove | - | Desna Chernigov | 2:1 | |
Ucrania