| 1. Jornada | 24.01.2022 | Alianza Petrolera | - | Deportivo Pereira | 2:1 | ||||
| 2. Jornada | 27.01.2022 | Unión Magdalena | - | Alianza Petrolera | 0:0 |  |
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| 3. Jornada | 31.01.2022 | Alianza Petrolera | - | Envigado FC | 2:2 | ||||
| 4. Jornada | 02.02.2022 | Atlético Bucaramanga | - | Alianza Petrolera | 2:1 | ||||
| 7. Jornada | 17.02.2022 | Alianza Petrolera | - | Cortuluá | 0:0 | ||||
| 8. Jornada | 20.02.2022 | Deportivo Cali | - | Alianza Petrolera | 1:1 | ||||
| 13. Jornada | 28.03.2022 | Alianza Petrolera | - | Patriotas FC | 2:1 |
Colombia