| 1. Jornada | 09.01.2022 | Cruz Azul | - | Club Tijuana | 2:0 |  |
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| 2. Jornada | 16.01.2022 | Club Tijuana | - | Club León | 1:1 | |
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| 3. Jornada | 29.01.2022 | Puebla FC | - | Club Tijuana | 3:1 | ||||
| 4. Jornada | 06.02.2022 | Club Tijuana | - | Pumas UNAM | 1:0 | ||||
| 5. Jornada | 12.02.2022 | Mazatlán FC | - | Club Tijuana | 2:0 | ||||
| 8. Jornada | 02.03.2022 | Deportivo Toluca | - | Club Tijuana | 1:2 | ||||
| 11. Jornada | 21.03.2022 | Club Tijuana | - | FC Juárez | 1:0 | ||||
| 9. Jornada | 07.04.2022 | Club Tijuana | - | Atlético San Luis | 1:1 | ||||
| 15. Jornada | 20.04.2022 | Deportivo Guadalajara | - | Club Tijuana | 2:1 |
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