| 4. Jornada | 03.02.2022 | Santa Fe | - | Atlético Junior | 2:1 | ||||
| 5. Jornada | 08.02.2022 | América de Cali | - | Santa Fe | 2:2 |  |
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| 6. Jornada | 13.02.2022 | Santa Fe | - | Deportivo Pereira | 1:2 | ||||
| 7. Jornada | 16.02.2022 | Deportes Tolima | - | Santa Fe | 3:0 | ||||
| 8. Jornada | 19.02.2022 | Santa Fe | - | Independiente Medellín | 1:0 | ||||
| 9. Jornada | 01.03.2022 | Patriotas FC | - | Santa Fe | 1:1 | |
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| 10. Jornada | 07.03.2022 | Santa Fe | - | Millonarios | 0:3 |  |
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| 12. Jornada | 22.03.2022 | Santa Fe | - | Atlético Bucaramanga | 3:1 | ||||
| 14. Jornada | 04.04.2022 | Santa Fe | - | Unión Magdalena | 1:0 | ||||
| 17. Jornada | 25.04.2022 | Millonarios | - | Santa Fe | 2:1 | ||||
| 20. Jornada | 15.05.2022 | Once Caldas | - | Santa Fe | 2:2 |
Colombia