| 6. Jornada | 07.03.2021 | Marathón | - | Honduras Progreso | 1:1 |  |
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| 7. Jornada | 11.03.2021 | Vida | - | Honduras Progreso | 1:1 | ||||
| 8. Jornada | 18.03.2021 | Honduras Progreso | - | Real España | 1:1 | |
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| 9. Jornada | 22.03.2021 | Honduras Progreso | - | Platense | 2:2 | |
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| 10. Jornada | 01.04.2021 | Lobos UPNFM | - | Honduras Progreso | 0:2 | ||||
| 11. Jornada | 12.04.2021 | Motagua | - | Honduras Progreso | 5:2 | ||||
| 12. Jornada | 18.04.2021 | Honduras Progreso | - | Olimpia | 0:5 | ||||
| 13. Jornada | 21.04.2021 | Real Sociedad | - | Honduras Progreso | 3:1 | ||||
| 14. Jornada | 28.04.2021 | Honduras Progreso | - | Real de Minas | 5:2 |
Honduras