| 2. Jornada | 13.08.2021 | Platense | - | Honduras Progreso | 1:1 | ||||
| 9. Jornada | 16.09.2021 | Honduras Progreso | - | Real España | 1:1 | ||||
| 10. Jornada | 20.09.2021 | Vida | - | Honduras Progreso | 1:0 |  |
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| 11. Jornada | 23.09.2021 | Victoria | - | Honduras Progreso | 1:2 | ||||
| 12. Jornada | 03.10.2021 | Honduras Progreso | - | Platense | 4:2 |  |
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| 13. Jornada | 09.10.2021 | Marathón | - | Honduras Progreso | 2:1 | ||||
| 14. Jornada | 17.10.2021 | Honduras Progreso | - | Lobos UPNFM | 0:1 | ||||
| 15. Jornada | 24.10.2021 | Honduras Progreso | - | Olimpia | 0:2 | |
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| 17. Jornada | 01.11.2021 | Honduras Progreso | - | Real Sociedad | 2:1 | ||||
| 18. Jornada | 10.11.2021 | Motagua | - | Honduras Progreso | 3:2 |
Honduras