| 1. Jornada | 08.08.2021 | FC Metz | - | Lille | 3:3 | ||||
| 2. Jornada | 14.08.2021 | Lille | - | Niza | 0:4 |  |
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| 3. Jornada | 21.08.2021 | Saint-Étienne | - | Lille | 1:1 | ||||
| 4. Jornada | 29.08.2021 | Lille | - | Montpellier | 2:1 |  |
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| 5. Jornada | 10.09.2021 | Lorient | - | Lille | 2:1 | ||||
| 6. Jornada | 18.09.2021 | RC Lens | - | Lille | 1:0 | ||||
| 7. Jornada | 22.09.2021 | Lille | - | Stade de Reims | 2:1 | |
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| 8. Jornada | 25.09.2021 | RC Strasbourg | - | Lille | 1:2 | ||||
| 9. Jornada | 03.10.2021 | Lille | - | Marsella | 2:0 | ||||
| 10. Jornada | 16.10.2021 | Clermont Foot 63 | - | Lille | 1:0 | ||||
| 12. Jornada | 29.10.2021 | París Saint-Germain | - | Lille | 2:1 | ||||
| 13. Jornada | 06.11.2021 | Lille | - | Angers | 1:1 | ||||
| 14. Jornada | 19.11.2021 | Mónaco | - | Lille | 2:2 | |
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| 15. Jornada | 27.11.2021 | Lille | - | Nantes | 1:1 | ||||
| 17. Jornada | 04.12.2021 | Lille | - | Troyes | 2:1 |
Turquía