| 2. Jornada | 23.05.2021 | Plaza Colonia | - | Montevideo City Torque | 1:0 | ||||
| 3. Jornada | 29.05.2021 | Villa Española | - | Plaza Colonia | 1:3 | ||||
| 1. Jornada | 02.06.2021 | Peñarol | - | Plaza Colonia | 0:0 | ||||
| 4. Jornada | 05.06.2021 | Plaza Colonia | - | Nacional | 1:2 | ||||
| 5. Jornada | 12.06.2021 | Cerrito | - | Plaza Colonia | 1:2 |  |
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| 6. Jornada | 17.06.2021 | Plaza Colonia | - | Liverpool | 2:1 | |
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| 7. Jornada | 22.06.2021 | River Plate | - | Plaza Colonia | 0:1 | ||||
| 8. Jornada | 28.06.2021 | Plaza Colonia | - | Cerro Largo | 1:1 | ||||
| 9. Jornada | 05.07.2021 | Progreso | - | Plaza Colonia | 1:2 | ||||
| 10. Jornada | 10.07.2021 | Plaza Colonia | - | Sud América | 1:0 | ||||
| 11. Jornada | 17.07.2021 | Deportivo Maldonado | - | Plaza Colonia | 0:1 | ||||
| 12. Jornada | 01.08.2021 | Fénix | - | Plaza Colonia | 0:1 | |
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| 13. Jornada | 09.08.2021 | Plaza Colonia | - | Boston River | 0:0 | |
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| 14. Jornada | 16.08.2021 | Montevideo Wanderers | - | Plaza Colonia | 0:2 | ||||
| 15. Jornada | 22.08.2021 | Plaza Colonia | - | Rentistas | 2:0 |
Uruguay