| 1. Jornada | 06.02.2022 | Boston River | - | Plaza Colonia | 0:0 | ||||
| 2. Jornada | 12.02.2022 | Plaza Colonia | - | River Plate | 0:1 | ||||
| 3. Jornada | 19.02.2022 | Cerro Largo | - | Plaza Colonia | 0:5 |  |
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| 4. Jornada | 25.02.2022 | Plaza Colonia | - | Fénix | 1:1 | |
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| 5. Jornada | 12.03.2022 | Defensor Sporting | - | Plaza Colonia | 0:0 | ||||
| 6. Jornada | 20.03.2022 | Plaza Colonia | - | Albion | 1:1 |
Uruguay