| 1. Jornada | 17.02.2022 | Cobreloa | - | San Luis | 2:1 | ||||
| 2. Jornada | 23.02.2022 | San Luis | - | CD Magallanes | 0:2 | ||||
| 3. Jornada | 03.03.2022 | Barnechea | - | San Luis | 3:1 | ||||
| 4. Jornada | 10.03.2022 | San Luis | - | Santiago Wanderers | 1:1 | ||||
| 6. Jornada | 23.03.2022 | Rangers | - | San Luis | 2:3 | ||||
| 10. Jornada | 22.04.2022 | Puerto Montt | - | San Luis | 1:1 | ||||
| 18. Jornada | 05.07.2022 | San Luis | - | Cobreloa | 0:0 |  |
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| 22. Jornada | 01.08.2022 | Santiago Morning | - | San Luis | 1:0 | ||||
| 24. Jornada | 16.08.2022 | Deportes Copiapó | - | San Luis | 1:1 |  |
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| 25. Jornada | 24.08.2022 | San Luis | - | Unión San Felipe | 2:2 | ||||
| 26. Jornada | 31.08.2022 | Deportes Melipilla | - | San Luis | 1:2 | |
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| 27. Jornada | 08.09.2022 | San Luis | - | Puerto Montt | 0:3 | ||||
| 29. Jornada | 27.09.2022 | Deportes Temuco | - | San Luis | 1:0 | ||||
| 30. Jornada | 04.10.2022 | San Luis | - | Deportes Iquique | 0:0 | ||||
| 31. Jornada | 10.10.2022 | Fernández Vial | - | San Luis | 1:1 | |
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| 32. Jornada | 16.10.2022 | San Luis | - | Santa Cruz | 0:0 | ||||
| 33. Jornada | 24.10.2022 | San Luis | - | Recoleta | 2:1 | ||||
| 34. Jornada | 01.11.2022 | Universidad de Concepción | - | San Luis | 3:1 |
Chile