| 1. Jornada | 24.04.2021 | New York City FC | - | FC Cincinnati | 5:0 | ||||
| 6. Jornada | 12.09.2021 | FC Cincinnati | - | Toronto FC | 2:0 | ||||
| 6. Jornada | 16.09.2021 | Atlanta United FC | - | FC Cincinnati | 4:0 | ||||
| 6. Jornada | 26.09.2021 | D.C. United | - | FC Cincinnati | 4:2 | ||||
| 7. Jornada | 10.10.2021 | FC Cincinnati | - | Philadelphia Union | 1:2 | ||||
| 7. Jornada | 17.10.2021 | FC Cincinnati | - | Orlando City | 0:1 |  |
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| 7. Jornada | 21.10.2021 | FC Cincinnati | - | Chicago Fire | 3:4 | |
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| 7. Jornada | 24.10.2021 | Inter Miami CF | - | FC Cincinnati | 5:1 | ||||
| 7. Jornada | 28.10.2021 | FC Cincinnati | - | Nashville SC | 3:6 | ||||
| 7. Jornada | 01.11.2021 | Philadelphia Union | - | FC Cincinnati | 2:0 | ||||
| 8. Jornada | 07.11.2021 | FC Cincinnati | - | Atlanta United FC | 1:2 |  |
Estados Unidos